This page was produced as an assignment for Genetics 677 at UW-Madison, Spring 2010

RNAi

The homolog that is produced by Homologene for C.elegans, egl-15, is described on its page on Wormbase as being "orthologous to FGFR1." This difference in description makes one wonder how accurately any studies on egl-15's function can be applied FGFR3. Perhaps though, the similarities between all of the members of the FGFR family accounts for the gene being listed as a homolog for more than one of them.
Egl-15 is required for sex myoblast migration, so some mutations in it cause an egg-laying defect which gives the gene its name. [1]

While I was unable to access the RNAi database, I found this chart on the egl-15 Wormbase page describing all of the observed phenotypes in experiments with RNAi on the gene.
Picture
Similar to the FGFR3 gene, changes in different parts of the egl-15 gene can produce very different phenotypes. However, since the mutation in mammals causes a phenotype that cannot occur in C.elegans it is difficult use these results to postulate what effect a similar interference could have in humans. I believe that a mammalian model organism would better show the results of any experimentation as well as the results being more easily transferred to human applications.

References

Created by Alex Joyce
ajoyce@wisc.edu
Last updated: Feb. 7, 2010
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